lean meat powder
clenbuterol hydrochloride
CAS: 21898-19-1
Molecular Formula: C12H19Cl3N2O
lean meat powder - Names and Identifiers
| Name | clenbuterol hydrochloride |
| Synonyms | nab365 NAB 365CL Clenbuterol HCl lean meat powder planiparthydrochloride clenbuterolclorhidrato clenbuterol hydrochloride Clenbuterol Hhydrochloride 4-amino-alpha-((tert-butylamino)methyl)-3,5-dichloro-benzylalcohomonohydr 4-amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzylalcoholhydrochlor 4-amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzylalkohol-hydrochlor |
| CAS | 21898-19-1 |
| EINECS | 244-643-7 |
| InChI | InChI=1/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H |
| InChIKey | OPXKTCUYRHXSBK-UHFFFAOYSA-N |
lean meat powder - Physico-chemical Properties
| Molecular Formula | C12H19Cl3N2O |
| Molar Mass | 313.65 |
| Melting Point | 174-175.5°C |
| Flash Point | 9℃ |
| Solubility | Soluble in water and in ethanol (96 per cent), slightly soluble in acetone. |
| Appearance | neat |
| Merck | 14,2347 |
| Storage Condition | 2-8°C |
| Use | For the prevention and treatment of bronchial asthma, chronic bronchitis and bronchitis with emphysema caused by bronchospasm |
lean meat powder - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DN3180000 |
| HS Code | 29221990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice, rats, guinea pigs (mg/kg): 176, 315, 67.1 orally; 27.6, 35.3, 12.6 i.v. (Ueberberg) |
lean meat powder - Standard
Authoritative Data Verified Data
This product is a-[(tert-butylamino) methyl]-4-amino -3, 5-dichlorobenzyl alcohol S salt. Calculated as dry product, containing C12H18C12N20 • HCl shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
lean meat powder - Trait
Authoritative Data Verified Data
- This product is white or white crystalline powder; Odorless.
- This product is dissolved in water or ethanol, slightly soluble in chloroform or acetone, insoluble in ether.
melting point
The melting point of this product (General rule 0612) is 172~176°C, and it is decomposed at the same time during melting.
Last Update：2022-01-01 15:04:40
lean meat powder - Introduction
This standard substance is mainly used for measuring instrument calibration, analytical method evaluation and quality control, as well as the content determination and residue detection of corresponding components in related fields such as food, hygiene, environment and agriculture. It can also be used for value traceability or as a standard liquid reserve solution. It is diluted step by step and configured into various standard solutions for work. 1. Sample Preparation This standard substance is made of pure clenbuterol hydrochloride with accurate purity and fixed value as raw material, chromatographic ethanol as solvent, and accurately prepared by weight-volume method. Clenbuterol Hydrochloride, English Name: Clenbuterol Hydrochloride,CAS Number: 21898-19-1 2. Traceability and Determination Method This standard substance takes the configuration value as the standard value, and uses high performance liquid chromatography-diode array detector (HPLC-DAD) to compare this batch of standard substances with quality control control samples, and verify the preparation value. By using preparation methods, measurement methods and measuring instruments that meet the requirements of metrological characteristics, the traceability of the value of the standard substance is guaranteed. 3. characteristic value and uncertainty (see certificate) number name standard value (ug/mL) relative expansion uncertainty (%)(k = 2)BW10022 The uncertainty of clenbuterol hydrochloride 1004 standard value in ethanol is mainly synthesized by uncertainty components such as raw material purity, weighing, constant volume, uniformity and stability. 4. uniformity test and stability inspection According to the JJF1343-2012 [General Principles and Statistical Principles of Standard Substance Setting], random sampling of sub-packed samples is carried out, uniformity test of solution concentration is carried out, and stability inspection is carried out. The results show that the standard material has good uniformity and stability. The standard substance is valid for 18 months from the date of setting the value. The development unit will continue to monitor the stability of the standard substance. If the value changes are found during the validity period, the user will be notified in time. 5. packaging, transportation and storage, use and precautions 1. Packaging: This standard substance is packed in borosilicate glass ampoules, about 1.2 mL/branch. When removing or diluting, the pipette quantity shall prevail. 2. Transportation and storage: normal temperature transportation, transportation should avoid extrusion and collision; Refrigerate (2~8)℃ and store in a cool place. 3. Use: Balance at room temperature (20±3 ℃) before unsealing, and shake well. Once the ampoule is opened, it should be used immediately and cannot be used as a standard substance after being fused again.
Last Update：2022-10-16 17:15:00
lean meat powder - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, add 1 ml of water to dissolve, add 20% sulfuric acid to make a saturated solution of potassium permanganate 5ml, shake for several minutes, then add an appropriate amount of oxalic acid, shake to make the solution fade and clear, after 5ml of water was added, a perchloric acid solution of 2, 4-dinitrophenylhydrazine (1.2g of 2, 4-dinitrophenylhydrazine was dissolved by adding 50ml of 30% perchloric acid solution) was added, and a precipitate was precipitated.
- take this product, add 0.1 mol/L hydrochloric acid solution was prepared as a solution containing 30ug per 1 ml, and had a maximum absorption at a wavelength of 0401 nm and NM as determined by ultraviolet-visible spectrophotometry (general).
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 351).
- This product shows the identification reaction of aromatic first amines (General rule 0301).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:04:41
lean meat powder - Exam
Authoritative Data Verified Data
clarity and color of solution
take 0.5g of this product and add 0901 of water. After shaking and dissolving, the solution should be clear and colorless. If it is colored, it should be compared with the yellow No. 1 Standard Colorimetric solution (General rule first method), not deeper.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 15:04:42
lean meat powder - Content determination
Authoritative Data Verified Data
take about 0.25g of this product, weigh it accurately, put it in a 100ml beaker, add 25ml of hydrochloric acid solution (1-2) to dissolve, then add 25ml of water, according to the permanent stop titration method (General 0701), with sodium nitrite titration solution (0.05mol/L) titration. Each 1 ml of sodium nitrite titration solution (0.05mol/L) corresponds to 15.68mg of C12H18C12N20-HCl.
Last Update：2022-01-01 15:04:42
lean meat powder - Category
Authoritative Data Verified Data
B-adrenoceptor agonists.
Last Update：2022-01-01 15:04:43
lean meat powder - Storage
Authoritative Data Verified Data
light shielding, closed storage.
Last Update：2022-01-01 15:04:43
lean meat powder - Clenbuterol hydrochloride suppositories
Authoritative Data Verified Data
This product contains clenbuterol hydrochloride (C12H18C12N20 • HCl) should be 85.0% ~ 115.0% of the label amount.
trait
This product is white or milky white suppository.
identification
take 5 capsules of this product, add 10ml of water, place it on a water bath and heat it to melt the matrix, stir it evenly, let it cool, take the water layer, filter it, and take the filtrate according to the identification under clenbuterol hydrochloride (4), (5) the test showed the same response.
examination
should comply with the relevant provisions under suppository (General rule 0107).
Content determination
Take 20 capsules of this product, precision weighing, cut into small pieces, precision weighing an appropriate amount (about 0.36mg equivalent to clenbuterol hydrochloride), put it in a separatory funnel, heated chloroform 20ml to dissolve, extract with hydrochloric acid solution (9-100) by shaking for 3 times (20ml, 15ml, 10ml), separate the acid extract, place it in a 50ml measuring flask, and dilute to the scale with hydrochloric acid solution (9-100), shake well, filter, and take the filtrate as the test solution; Take an appropriate amount of clenbuterol hydrochloride reference substance, precision weigh, add hydrochloric acid solution (9-100) the solution containing 7.2ug per 1ml was prepared as a control solution by dissolution and quantitative dilution. Take 15ml of reference solution and 15ml of test solution respectively, put them in 25ml measuring flask, add 5ml of hydrochloric acid solution (9-100) and 1ml of 0.1% sodium nitrite solution respectively, shake well, and place them for 3 minutes, add 1ml of 0.5% Ammonium sulfamate solution each, shake well and shake for 10 minutes, then add 1ml of 0.1% naphthoethylenediamine hydrochloride solution each, shake well, place for 10 minutes, dilute to the scale with hydrochloric acid solution (9-100), shake well, according to ultraviolet-visible spectrophotometry (General rule 0401), the absorbance was measured at a wavelength of NM and calculated.
category
Same as clenbuterol hydrochloride.
specification
60ug
storage
protected from light, sealed and stored at 30°C or lower.
Last Update：2022-01-01 15:04:44
lean meat powder - Reference Information
| Properties | Clenbuterol hydrochloride is a white or almost white crystalline powder; odorless, slightly bitter taste. It is dissolved in water or ethanol, slightly soluble in chloroform or acetone, and insoluble in ether. |
| Pharmacological effects | The chemical structure of clenbuterol hydrochloride is similar to that of adrenergic drugs. It is an adrenergic drug and is a 2-receptor agonist. It has a high selective agonistic effect on the 2-receptors of bronchial, uterine and vascular smooth muscle, and can effectively relieve bronchospasm. In addition, there are strong anti-allergic and significantly enhance the activity of bronchial cilia, and act on the lysosome, which can promote mucus dissolution and facilitate the discharge of sputum. Clinically, it is mainly used for bronchial asthma and wheezing bronchitis. It has a strong and long-lasting effect. It is the main drug to prevent bronchial asthma and bronchospasm. Due to the small amount of this drug (oral dose of 20~40g), and the effect after medication Fast and long maintenance time, so this drug was included in the Second Pharmacopoeia of the People's Republic of China in 2000. Its mechanism of action has been basically clarified. |
| Selective adrenergic β2 receptor agonist | Clenbuterol hydrochloride (clenbuterolhydrochloride), the appearance is a white crystalline powder, the chemical name is hydroxymethyl tert-butinepinephrine or 2-[(tert-butylamino) methyl]-4-amino -3, 5-dichlorobenzene methanol hydrochloride, the drug name is dicloroamine, sulchuanning, quansu, etc. It is a potent selective adrenaline β2 receptor agonist, which can relax bronchial smooth muscle and is used to treat bronchial asthma, asthmatic bronchitis and bronchitis with emphysema. The main ingredient of "Clenbuterol" is clenbuterol hydrochloride. Because it has the effect of promoting protein synthesis in muscle, promoting fat decomposition, and reducing fat accumulation in animals, it can relatively increase the lean meat of animals, thereby improving the quality of animals. It is also called "growth promoter" and "nutritional weight agent". In the early 1960s, it was discovered that it could promote animal growth. In the 1970s, the United States introduced it into livestock and poultry production and became the most widely used β-stimulant in the world. However, because the substance has strong thermal stability and biochemical stability, animals can form accumulative residues in internal organs and tissues after eating it. People who eat pork containing clenbuterol will have symptoms of poisoning. Therefore, countries around the world soon banned the application of β-stimulants in animal husbandry, and many countries have formulated detection methods for monitoring β-stimulant residues and clenbuterol hydrochloride in feed. Our government banned clenbuterol as a feed additive in 1997. Precautions: A small number of patients may have mild palpitations, hand tremors, dizziness and other adverse reactions, continue to take medicine generally can gradually disappear. Use with caution in patients with hyperthyroidism, tachycardia or hypertension. Preparations: Tongtong tablets, aerosols, suppositories, films, patches, etc. (2016-02-01) Figure 1 is the structural formula of clenbuterol hydrochloride |
| use | is used to prevent and treat bronchial asthma, chronic bronchitis and bronchitis with emphysema. It is used to prevent and treat bronchospasm caused by bronchial asthma, chronic bronchitis and bronchitis with emphysema β2-adrenoceptor agonist, bronchodilator. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | abdominal cavity-mouse TDL0: 2 mg/kg |
| flammability hazard characteristics | combustible, decomposition of toxic chlorides during combustion, nitrogen oxide gas |
| storage and transportation characteristics | warehouse is low temperature, ventilated and dry; Store separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, dry powder, sand |
Last Update：2024-04-09 20:49:11
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